The regular cast was headed by Terence Donovan as the hotel manager, and also included Carmen Duncan, George Spartels, and American actor Richard Lawson.
Interior sequences were largely shot on video at Channel Ten's Nunawading studios, giving the series a soap opera look.
In Melbourne, ATV-O ran full-page advertisements in newspapers on the day the first episode was shown, describing it as "The most discussed TV series produced this year", ending with "You be the judge".
[2] Former The Box regular and Network Ten weather girl Christine Broadway also made a guest appearance in one episode.
“Hotel Story” was also the debut show that future TV actress, sex symbol and animal campaigner Lynda Stoner played a guest role too.