British-born Ann Atkinson (Lynn Redgrave), as hospital administrator, had three unruly doctors with whom to cope, and the comedy arose from their interactions.

Other characters who were part of the series were Head Nurse Bradley (Aneta Corsaut), a sympathetic and level-headed influence, Mrs. Phipps (Deedy Peters), a somewhat over-the-hill but enthusiastic candystriper, always forcing her good intentions upon unwilling patients, and Conrad Peckler (Mark L. Taylor), who was brought in as the arch villain of the piece to bring order to the hospital, hated by all.

She insisted on bringing her daughter to work, in part, because she wanted to be able to breast-feed the baby on schedule, but this was interpreted by the studio as holding out for more money, while being disruptive to shooting requirements.

Redgrave sued Universal for breaking her existing contract, but was not rehired, and the suit was dismissed several years later.

(The breast-feeding controversy was later spoofed on Second City Television in a sketch titled "Wet Nurse", with Andrea Martin playing Redgrave as a nurse with gigantic breasts solving several crises at a hospital) Universal replaced Redgrave with Sharon Gless, who was then under a 10-year contract with Universal, but the show's previously excellent ratings suffered from the abrupt and clumsily handled transition (Ann announced her departure in a letter read out loud by Charlie), and the series was cancelled by early 1982 despite still finishing the season in the top 25.