The House of Bourbon-Braganza (Spanish: Casa de Borbón-Braganza; Portuguese: Casa de Bourbon-Bragança) was an Iberian noble house that had its origins in a royal marriage arranged in 1785 between Gabriel of Bourbon, Infante of Spain and Mariana Victoria of Braganza, Infanta of Portugal.

Their surviving son, Infante Pedro Carlos of Spain and Portugal (1786–1812), was brought up in the Portuguese court, first in Lisbon and, after 1807, in Rio de Janeiro.

Until 1793, he was the only grandson of Queen Maria I, and therefore considered as a potential heir of the Portuguese throne.

When the Portuguese royal family returned to Europe, Sebastian went to live in Spain (1822); but, due to his support to the Carlist pretender, he returned to Portugal (1865), where King Luís I gave him a warm reception.

Yet there are still distant female-line descendants, represented among the Spanish nobility (Dukes of Marchena, Durcal, and Ansola).