The drama centers on a group of musicians and dancers from the Imperial Music Bureau during the prosperous Tang dynasty of China.

It stars Bobby Au-yeung and Linda Chung as the main leads, with Myolie Wu, Evergreen Mak, Angela Tong, Yoyo Chen and JJ Jia as the major supporting cast.

During the production of House of Harmony and Vengeance, the drama was given the working title "樂府藏龍" (jyutping: ngok6 fu2 cong4 lung4; pinyin: yuèfǔ cánglóng; literally "Music Bureau's Hidden Dragon"), a word play on the Chinese proverb "臥虎藏龍" (jyutping: ngo6 fu2 cong4 lung4; pinyin: wòhǔ cánglóng), which refers to the undiscovered talents that lie beneath the surface of a normal-looking individual.

Producer Nelson Cheung cast Bobby Au-yeung, Sheren Tang, Moses Chan, and Myolie Wu in the lead roles in November 2010.

To focus on his coffee shop business, Chan withdrew from the production in early April 2011,[3] a month before filming commenced.