The branch was mainly settled in the Palazzo Loredan in Campo Santo Stefano, which they acquired in 1536 from the Mocenigo family.

[1] The progenitor of the family is considered to be Gerolamo Loredan di S. Vitale (d.~1474), known as "dal Barbaro", who served as the podestà of Padua.

In the will drawn up in February 1474 in Padua where he was podestà, the father designated Leonardo as the executor of the will and the sole heir of the estate and granted Pietro an annual annuity of 250 ducats.

[2] Their sister, Caterina Loredan, who later became Dogaressa of Venice by marriage to Doge Antonio Grimani, was described in a book by Edgcumbe Staley: “The Loredanian tradition for patriotism and nobility was handed on in the gracious personage of Dogaressa Caterina Loredan, sister of Doge Leonardo Loredan – the Consort of his successor Doge Antonio Grimani.”[3] In 1461, Leonardo Loredan married Giustina Giustiniani, of the wealthy branch of S. Moisè, with whom he had nine children: Lorenzo (who became Procurator of St. Mark's), Girolamo (the only one to continue the branch), Alvise, Vincenzo (died in Tripoli in 1499), Bernardo, Donata, Maria (wife of Giovanni Venier, of the branch that gave birth to Doge Francesco Venier), Paola (wife of Giovanni Alvise Venier, descendant of Doge Antonio Venier), and Elisabetta.

Andrea Loredan (d. 1750) died young, thus ending the male (agnatic) line of the branch of Santo Stefano.

On the 23rd of December, 1535, the Loredan family acquired the town of Barban in Istria (today part of Croatia) for 14,760 ducats, and ownership was held by the brothers Leonardo, Lorenzo and Francesco, of the Santo Stefano branch.