The Scarlet Witch, her twin brother Quicksilver, and their father (at the time) Magneto play major roles in the series.

Like the Age of Apocalypse (1995–1996) storyline, House of M replaced the Earth-616 as the main reality for a brief time until Scarlet Witch reverted it to normal.

The epilogue to the House of M and Decimation story-lines, served to answer the mystery of the strange "energy-cloud" hovering in orbit around the Earth after House of M #8, was revealed in the pages of New Avengers #16–20 In this world, Magneto was attacked by Sentinels in Manhattan in 1979 (taking advantage of Marvel's sliding timescale policy, no heroes were active in the 1970s).

At the end of the attack, Magneto revealed an alleged international anti-mutant conspiracy involving Richard M. Nixon.

Secondly, he wanted to be acknowledged as a heroic figure and the rightful leader of all mutant-kind (hence the disappearance of Charles Xavier and the timing of Magneto's rise to dominance before other superheroes had appeared on the scene to challenge him).

It is unclear whether the Scarlet Witch altered the entire Marvel Universe, or merely the structure and history of Earth, a fact further complicated by the events of Secret Invasion.

[citation needed] Wanda Maximoff, also known as the Scarlet Witch, is living on the devastated island of Genosha under the care of Professor Charles Xavier and her father (at the time) Magneto.

Professor X informs Magneto that his telepathic powers will no longer be enough to hold back Wanda's reality-warping abilities and that a permanent solution must be found.

Captain America argues that the group should seek alternate methods of dealing with Wanda, including suppression of her powers and her insanity.

The X-Men argue that if word gets out that a mutant with the ability to change reality went insane, it would "send human-mutant relations back to the stone age."

As the conversation progresses, it is revealed that Professor X asked Doctor Strange to help Wanda, but unfortunately neither was strong enough to combat her magic.

Back in Genosha, Quicksilver rushes to Magneto to reveal that he was in New York City and heard that the X-Men and Avengers are planning on killing Wanda.

When the light departs, the world has changed: Spider-Man is a celebrity married to Gwen Stacy; Cyclops and Emma Frost are married; Doctor Strange is a psychologist; Carol Danvers is Captain Marvel, America's most beloved superhero; Gambit is a criminal; and Steve Rogers is an aged veteran.

Wolverine and the Human Resistance awaken many heroes to the truth, including Cyclops, Spider-Man, Shadowcat, Doctor Strange, Iron Man, She-Hulk, Daredevil, Rogue, Mystique, Nightcrawler, Toad, and Spider-Woman.

The heroes attack Magneto and his family directly, while Cloak, Emma Frost, Doctor Strange, and Layla search for Xavier.

While the chaos ensues, the Scarlet Witch disappears from the battlefield only to be discovered by Doctor Strange in a tower with her children.

After a heated exchange, Hawkeye is killed for the second time as one of the Scarlet Witch's antagonized sons uses his mutant powers to "erase" the Avenger.

The Avengers come together to try to make sense of what happened that night, only to be confronted by a distraught Doctor Strange, who states that the "House of M" timeline really took place, and its effects are slowly being felt on a wider scale.

In a May 5, 2008, interview, Brian Michael Bendis indicated that the events of "House of M" play into the "Secret Invasion" storyline.

The five-issue limited series House of M: Avengers debuted in November 2007, written by Christos Gage and drawn by Mike Perkins.

[8] The series spans from 1979 to the present day and acts as a prequel to the original House of M miniseries, showing the formation of Luke Cage's Human Resistance Movement.

[9] The 2008 miniseries Civil War: House of M depicts how Magneto took over the world and made mutants the dominant race, as well as confirming that Xavier is indeed dead in this reality.

It also features House of M versions of Bolivar Trask, Bucky Barnes, Burner, Dragoness, Gateway, Graydon Creed, Lifter, Mimic, Nuke, Randall Darby, Slither, the Soviet Super-Soldiers (Crimson Dynamo, Darkstar, Red Guardian, Titanium Man, Ursa Major, Vanguard), Vashti Cleito-Son, and Warlord Krang.

Set right after Civil War: House of M, this miniseries depicts how the Hood assembles a gang of the deadliest "sapiens" super-criminals: Madame Masque, Absorbing Man, Batroc the Leaper, Blizzard II, Chemistro III, Cobra, Constrictor, Crossbones, Nitro, Sandman, Titania, Wizard, and the Wrecking Crew (Bulldozer, Piledriver, Thunderball, and Wrecker).

In the run-up to the 2014 "Spider-Verse" storyline, the Superior Spider-Man (Doctor Octopus's mind in Spider-Man's body) found himself temporarily trapped in the year 2099 with his attempts to return home via a dimensional portal resulting in him witnessing various alternate worlds where other Spider-Men had been killed by a dimension-hopping adversary including a dead Spider-Man in what appeared to be the world of the House of M.[10] The "House of M" storyline ties into the following comics: The trade paperbacks collect many of the issues involved with the House of M storyline.

Wanda Maximoff creates an alternate reality after Vision's death, although she only affects one town, Westview, instead of the whole world.