The House of Osorio is an old and influential Spanish noble family, which originated from the Kingdom of Castile.
They descend from count Osorio Martínez, a prominent nobleman in the first half of the 12th century who was member of the Flagínez family and husband to a granddaughter of king Alfonso VI of León.
It was from his grandson, Osorio González, that the family derived its patronymic surname.
He had three sons, Juan Álvarez Osorio, a court official and ancestor of the later noble family, Gonzalo Osorio, Bishop of Mondoñedo (d. 1326), and Álvar Núñez Osorio, Count of Trastámara, Lemos and Sarria, and mayordomo mayor before being executed by king Alfonso XI in 1329.
Later descendants would be Grandees of Spain and would hold numerous titles, including Marquess of Astorga and Duke of Alburquerque.