In 2001, Cypress Hill included a sequel to the song on their album Stoned Raiders entitled "Here Is Something You Can't Understand", using the same chorus but with new verses from B-Real, Sen Dog and guest Kurupt.

The music video features cameos by A Tribe Called Quest's Q-Tip and Tim Dog, as well as Ice Cube, with whom the group would later feud.

Rage Against the Machine performed the song on their DVD, Live at the Grand Olympic Auditorium, accompanied by Cypress Hill.

Singer Charlotte Sometimes named the first single from her debut album Waves and the Both of Us "How I Can Just Kill a Man" in honor of Cypress Hill, though the songs have no other similarities.

The song quickly became a staple on both VH1 and MTV during the summer of 2008 and closed her set on the Vans Warped Tour.