[1] The Lamesa campus was established in 1972 and the first class in San Angelo was held the following year.

[2] In August 1980 the school opened the Southwest Collegiate Institute for the Deaf on 57 acres (23 ha) of the former Webb Air Force Base, and it took over a nursing program in San Angelo the following year.

[1] There are branch campuses in San Angelo, Lamesa, and at the SouthWest College for the Deaf in Big Spring; the college also offers programs at the Big Spring Federal Correctional Institute and the Eden Detention Center.

As defined by the Texas Legislature, the official service area of Howard College is Howard, Dawson, Martin, Glasscock, Sterling, Coke, Tom Green, Concho, Irion, Schleicher, Sutton, Menard, and Kimble counties.

[5] After winning in 1991, Howard won the Junior College (JUCO) World Series a second time, in 2009, with a season record of 63–1.