Howardville is a city in New Madrid County, Missouri, United States.

Howardville was founded by Travis B. Howard, a prominent black educator and activist in the mid-20th century Bootheel region.

A graduate of Tuskegee Institute, Howard was inspired by Booker T. Washington's belief that land ownership was among the critical factors in lifting African Americans out of poverty.

In the late 1940s, Howard purchased 200 acres (81 ha) of land encompassing much of what is now Howardville, and sold off lots to displaced black sharecroppers.

The city of Lilbourn lies just to the north along County Road D, and Marston to the south along US 61.

According to the United States Census Bureau, the city has a total area of 0.23 square miles (0.60 km2), all land.

The racial makeup of the city was 5.74% White, 92.43% Black or African American, 1.04% Asian, and 0.78% from two or more races.

The racial makeup of the city was 7.02% White, 92.40% African American, and 0.58% from two or more races.