In 1945, she graduated from the Tbilisi Art academy, majoring in sculpture, minor ceramics (several Professors Y. Nicoladze, S. Kobuladze).

From 1956 she took over the position of head of ceramics department of the Yerevan State Art and Theatre institute, in 1977 she was awarded with a professor degree.

Armenia is expressed through Ripsime's art through the shape and coloring of her ceramics, in the characteristics of the ornaments and in the images which form the basis of her works.

In her art Ripsime Simonyan also touches upon the literature of Armenia: the national myths and legends, the poetry of Sayat-Nova and of Hovhannes Tumanyan, the delicate and rich lyrics of Avetik Isahakyan, the passionate world of Eghishe Charents' images.

Simonyan connects her art with well-known artistic figures and created a whole gallery of portrait statues of Aram Khachaturian, Konstantin Saradzhev, Avetik Isahakyan, Stepan Zoryan, Zenaida Pally, Ruben Paronyan and others from 1950 to 1958.