In 2016, Huang Zhengyu was promoted to Chinese Super League side Guangzhou R&F first team by manager Dragan Stojković.

[1] He made his senior debut on 2 July 2016 in a 4–2 home victory against Shijiazhuang Ever Bright, coming on as a substitute for Lu Lin in the 87th minute.

[2] Huang played six league match for Guangzhou in the 2016 season and extended his contract with the club on 7 November 2016 for five years.

[3] Huang became a regular starter for Guangzhou R&F in the 2017 season, benefitting from the new CSL regulation that at least one under-23 player must be in the starting line-up.

[8] On 18 September 2016, Huang was selected in the China national under-19 football team for the 2016 AFC U-19 Championship.