Shi Ke started his football career in 2006 when he joined Hangzhou Greentown's youth academy from Wuxi Sports School.

He scored his first goal for the club on 28 February 2017 in a 5–1 win against Western Sydney Wanderers in the 2017 AFC Champions League.

[4] After six seasons in Shanghai, Shi would join fellow top tier club Shandong Taishan on 20 February 2021.

[5] He made his debut for the club on 20 April 2021 in a league game against Chongqing Liangjiang Athletic that ended in a 2-0 victory.

Shi continued to play for the under-20 national team in the 2011 Toulon Tournament and was appointed as captain by then manager Jan Olde Riekerink.