Besides Azaria, the cast included Paget Brewster, Blythe Danner (who won the Emmy Award in 2005 and 2006 for Outstanding Supporting Actress in a Drama Series for her role as Izzy), Oliver Platt, Anton Yelchin, Andy Comeau, Kimberly Brooks, Liza Lapira, and Faith Prince.

Those making recurring guest appearances on the show during its first season included Lara Flynn Boyle, Robert Forster, Swoosie Kurtz, Annie Potts, and Faith Prince.

The series was created by Bob Lowry and features Hank Azaria as Dr. Craig "Huff" Huffstodt, a psychiatrist whose life changes abruptly when a 15-year-old client commits suicide in his office.

Two days before the finale, Showtime announced that the show would not be picked up for a third season,[2] and several plotlines, including the resolution of pending criminal charges against Russell Tupper and the possibility of reconciliation between Huff and Beth, were left unresolved.

Huff - The Complete 2nd Season was made available in 2012 as a three-disc DVD set, but is only produced via a "manufacture on demand" format through Sony Pictures Home Entertainment.