[1][dubious – discuss] In 1814 he commenced the building of the Cambridge Street Cotton Mill in Chorlton-on-Medlock.
He was a local magistrate and one of the commanders of the Manchester and Salford Yeomanry responsible for the Peterloo Massacre at St Peter's Field in 1819.
[2] He assisted the Swiss inventor-engineer Johann Georg Bodmer by making space available to him at his Chorlton Mills and was instrumental in founding the Royal Victoria Gallery of Practical Science in 1839.
[3] He was associated with the Royal Manchester Institution[4] and a moving force in the establishment of Owens College.
[6] Hugh Hornby Birley died in 1845 and was buried in the family vault in St Peter's Church, Manchester.