He was the grandson of Hugh McCulloch who was Secretary of the Treasury under Presidents Lincoln, Johnson, and later Arthur.
He attended Harvard University and served as an English assistant there from 1892 to 1894.
Inspired by the Pre-Raphaelites and decadents,[2] his verse was praised for its "careful technique and reserve power.
He died on March 27, 1902, in Florence, Italy, shortly before he would have turned 33.
McCulloch was a member of a group of Harvard poets, described by George Santayana as having been "alone against the world", who died young, including George Cabot Lodge, Trumbull Stickney, Thomas Parker Sanborn and Philip Henry Savage.