Part of the facility was used for the elderly and disabled, and some of the land north of modern Forest Hill Avenue still in such use at the beginning of the 21st century.

About the same time, Meadowbrook High School, also located close to the border with Richmond, was built to a similar plan.

At almost the same time as the annexed area was added to the city, Richmond Public Schools began a court-ordered desegregation busing program in the fall of 1971.

Other students who lived close to Huguenot were assigned as far away as the former John F. Kennedy High School, located past the opposite side of Richmond's city limits in the edge of Henrico County.

The river's location running lengthwise through the center of the city and the limited number of bridges in 1971 added to the transportation riding times and mileage.

Within a year, white flight became evident in residential housing patterns, especially in the annexed area, where the busing program was cited as a major objection by those leaving the city.

It resulted in combining Thomas Jefferson, Huguenot, and George Wythe into one unique school in three widely separated facilities.

On August 1, 2016, Democratic vice-presidential nominee and Senator from Virginia Tim Kaine addressed a crowd in the new school's gymnasium as part of the Clinton-Kaine campaign.

[3] On June 6, 2023, a mass shooting occurred at Monroe Park, outside the Huguenot High School graduation ceremony.