The name was changed to Manchester District High School in 1924, with the first graduating class, in 1925, consisting of eight students.

Westward urban sprawl from the nearby city of Richmond, Virginia, required yet another move in 1992 to the current location at 12601 Bailey Bridge Road.

In 2003 closed-circuit cameras were installed in the building and parking lots to provide better security for students and staff.

An addition to the main building was completed in 2004 to house the Mass Communications and Spanish-Immersion Specialty Centers.

In 2018, Manchester High School won the Class 6 Virginia State Championship in Football.