Jesuits founded a school of indigenous languages here in 1580 in the village which was then called San Antonio Huixquilucan, taking advantage of a parish left vacant by the death of its former priest.

It borders (counter-clockwise from north) the municipalities of Naucalpan, Lerma, Ocoyoacac, and the boroughs of Cuajimalpa and Miguel Hidalgo of the Distrito Federal (Mexico City).

[2] The largest localities (cities, towns, and villages) are:[2] Before the Spanish Conquest, the area was known as Cuautlalpan or Sierra de Las Cruces, and was inhabited by the Otomis.

They originally lived in the highlands, gathering the abundant vegetation and hunting rabbits, hares, armadillos, deer and raccoons.

Adoratorios dedicated to a god called Otontecutli are found in the caves, monoliths and sacred rocks of the upper elevations.

Later, the area would be under the control of various Spaniards like Primer Viceroy Antonio de Mendoza and indigenous rulers like Totoquiahuatzin, the governor of Tlacopan.

Since 1960, the municipality of Huixquilucan has experienced explosive growth in population and infrastructure because of its proximity to Mexico City.