[1] In 1915, her work at Southern University ended, Lyttle returned to Nashville and passed the Tennessee State Board Examiners nursing licensing exam.
[1] After retiring from Meharry, Lyttle spent a year at United Service Organizations (USO) in North Carolina.
[1] Lyttle organized the first Lambda Pi Alpha Sorority in 1930 at Meharry Medical College School of Nursing.
[6] By 1931 there were seven chapters located across the United States in Nashville, Tennessee, Atlanta, Georgia, Kansas City, Missouri, Indianapolis, Indiana, and New Orleans, Louisiana.
[1] In June 1946, the student nurses' residence at Meharry was named Hulda Margaret Lyttle Hall.
[7] In 2009 Meharry received a one million dollar grant from U.S. Department of Interior American Recovery and Reinvestment Act for repairs and restoration.