Humansville is a city in Polk County, Missouri, United States.

[4] Humansville was named after an American settler, Judge James G. Human, who settled in the area in 1834.

[6] During the Civil War, a skirmish was fought on the town's outskirts on March 26, 1862, in which approximately 300 to 400 Missouri Confederates under Col. James M. Frazier of Cedar County clashed with two companies of pro-Union Missouri State Militia.

[7] The George Dimmitt Memorial Hospital was listed on the National Register of Historic Places in 2012.

[8] Humansville sits on Brush Creek and the line of the old Kansas City, Clinton and Springfield Railway.

It is 18 mi (29 km) northwest of Bolivar, the seat of Polk County.

[9] Humansville is part of the Springfield, Missouri Metropolitan Statistical Area.

Intercity bus service to the city is provided by Jefferson Lines.