Forty thousand acres (160 square kilometers) of the county are underwater and used to grow catfish.

About 60% of U.S. farm-raised catfish is raised within a 65-mile (105 km) radius of the county seat, Belzoni.

The title "Catfish Capital" has also been claimed by Savannah, Tennessee, and Des Allemands, Louisiana.

In March 2023, the towns of Rolling Fork, Midnight and Silver City were struck by an EF4.

[3] As of the 2020 United States Census, there were 7,785 people, 3,186 households, and 2,078 families residing in the county.

Humphreys County has the seventh-lowest per capita income in Mississippi and the 56th-lowest in the United States.

In 2001 the Humphreys County Sheriff's Department named J. D. Roseman the first black Chief Deputy.