Wyatt-Brown was born in Eufaula, Alabama on February 14, 1884, the son of Eugene L. Brown and Serena Hoole.

He was awarded a Doctor of Divinity from St John's College in 1921 and Sewanee: The University of the South in 1933.

Wyatt-Brown was ordained deacon in May 1908 and served as assistant at St John's Church in Montgomery, Alabama.

From 1920 till 1928 he served as rector of Church of St Michael and All Angels in Baltimore.

He was consecrated on May 1, 1931, by Presiding Bishop James De Wolf Perry in St. Stephen's Cathedral in Harrisburg, Pennsylvania.