It was established by two Anglican clergyman in the year 1863 and the oldest affiliated institution of the University of Western Ontario.

The evangelical section of the Church of England obtained a charter for Huron, under the name of the Western University of London in 1878.

[6] A plaque was unveiled on 11 November 1997 to commemorate the lives of 18 Huron graduates who died in the First and Second World Wars.

[6] Its original property, known as Rough Park, occupied the block bounded by Grosvenor, St. George and St. James Streets.

In 1951, Huron moved to its present location and has since seen a growth in not only student enrollment, but also in its residence facilities, classrooms, library, and faculty offices.

[8] The Huron University College Corporation's Arms, Supporters, Flag and Badge were registered with the Canadian Heraldic Authority on 15 September 2005.

[10] The strategic plan for 2005–2010 aims to "nurture a sense of community respectful of individual differences and responsive to individual needs; to support an active student life which encourages the personal and intellectual growth of its members; and, through its chapel and theological programs, to affirm its heritage as an Anglican university."

The majority of students are enrolled in the Faculty of Arts and Social Sciences, which offers over 60 undergraduate programs of study.

[12] Rough Park, its original property, occupied the block bounded by Grosvenor, St. George and St. James Streets in London Ontario.

The Administrative Wing includes the Silcox Memorial Library, the Great Hall and the Chapel of St. John the Evangelist.

[14] Moreover, Huron has established a partnership with Harvard Business School, enabling students to earn online a Credential of Readiness (HBX CORe).

[18] After completing a research project, they are able to present their findings in a capstone CURL Showcase event at the end of the year.