[3] The Toronto Bible Training School was founded in 1894 by a group of brethren under the supervision of Elmore Harris pastor of Walmer Road Baptist Church.

The name of the school was changed to Toronto Bible College in 1912 and in September 1928 relocated to 16 Spadina Road (just north of Bloor Street and now Native Canadian Centre) when the lease expired.

[6] The founders' vision of TBC was to train laypeople as "Sunday School teachers, Pastors' Assistants, and as City, Home and Foreign Missionaries.

[13] In 1976 OBC relocated to a former Jesuit seminary (Regis College) on Ballyconnor Court in Willowdale, Toronto (formerly City of North York), designed by modernist architect Peter Dickinson.

The leadership intended the name change to indicate their vision to build "a world-class centre of Christian higher education in Canada.

[20] On December 5, 2007, Tyndale was given ministerial consent by the Province of Ontario to offer a Bachelor of Education program to prepare teachers for primary, junior, and intermediate grades.

[22] A key reason for Vatican approval of the pending transfer of the campus from Catholic to Protestant hands was Tyndale's commitment to maintain the aesthetically significant chapel as "sacred space".

[23] The facility transfer was completed on March 31, 2013, and all departments and offices were moved to 3377 Bayview Avenue in the Spring of 2015 with the adjacent high school continued to operate in that building until December 2020.

[33] Majors in business administration, English, history, philosophy, psychology, and religious studies receive a foundation of general knowledge before moving on to their areas of specialization.

Graduates of the sixteen-month Bachelor of Education (BEd) program are eligible for a Certificate of Qualification from the Ontario College of Teachers.

The Bachelor of Religious Education (BRE) is a three-year professional degree for students preparing for various forms of Christian ministry.

[37] Graduates of this program can move toward credentialing in the Province of Ontario to offer psychotherapy in agencies (secular or Christian) or in private practice.

[42] The Tyndale Family Life Centre offers professional counselling and supportive workshops for the larger community and members of the general public.

[50] Tyndale University was scheduled to have former President of the United States, George W. Bush, speak at a breakfast hosted by Prem Watsa of Fairfax Financial Holdings on September 20, 2011.