Hushpuckena is an unincorporated community located in Bolivar County, Mississippi, United States along U.S. Route 61.

Hushpuckena is located approximately 3 miles (4.8 km) south of Duncan and approximately 4 miles (6.4 km) north of Shelby.

Hushpuckena is located on the former Yazoo and Mississippi Valley Railroad.

[3] Hushpuckena is a name derived from the Choctaw language purported to mean "sunflowers are abundant".

This Bolivar County, Mississippi state location article is a stub.