O'Reilly is an unincorporated community located in Bolivar County, Mississippi, United States, along U.S. Route 61.

O'Reilly is approximately 3 miles (4.8 km) south of Boyle and approximately 6 miles (9.7 km) north of Shaw.

O'Reilly is located on the former Yazoo and Mississippi Valley Railroad.

[2] A post office operated under the name O'Reilly from 1903 to 1926.

This Mississippi-related article is a stub.