He is a member of the Hashemite dynasty, the royal family of Jordan since 1921, and is considered to be a 42nd-generation direct descendant of the Islamic prophet Muhammad.

Since reaching the age of majority in 2012, Hussein served as a regent on several occasions and has accompanied his father on a number of local and international visits.

Hussein is in charge of the Crown Prince Foundation, which is responsible for a technical university and a number of scientific and humanitarian initiatives.

[8] Though the title of crown prince was left vacant, the Constitution of Jordan provides for agnatic primogeniture: the monarch's eldest son is automatically first in the line of succession to the Jordanian throne unless decreed otherwise.

[8] The title was conferred on 2 July 2009 when a royal decree naming him as crown prince, effective immediately, was issued.

[10] Hussein performed his first official engagement in June 2010, when he represented his father at the celebrations of the anniversary of the Arab Revolt and the Armed Forces Day.

[10] Hussein is in charge of the Crown Prince Foundation, which is responsible for a technical university and a number of scientific & humanitarian initiatives.

[14] In 2013, Crown Prince Hussein participated in a training session with the members of the Jordanian special forces elite 71st Counter Terrorism Battalion.

[17][18] During the meeting, the prince oversaw a debate about methods of preventing young people from joining extremist groups.

[17] In May 2017, Hussein made the welcoming speech during a session of the World Economic Forum that was held on the Jordanian shores of the Dead Sea.

[10] On 17 August 2022, the Royal Hashemite Court announced the engagement of Crown Prince Hussein to Saudi citizen Rajwa Al Saif.