He was named Crown Prince of Jordan on 7 February 1999, a position he held until his older half-brother, King Abdullah II, rescinded it on 28 November 2004.

He then joined the Royal Military Academy Sandhurst, passing out as a commissioned officer in the Jordan Arab Legion in December 1999, with a number of prizes including the Sandhurst Overseas Sword, granted to the best overseas cadet and the HRH Prince Saud Abdullah Prize, presented to the cadet with the best aggregate mark in academic subjects.

On the same day, in compliance with his father's wish, King Abdullah II decreed that he, in turn, would be succeeded not by a son of his own but by his half-brother, Hamzah, who was therefore accorded the title of crown prince.

[6] In a letter from Abdullah to Hamzah, read on Jordanian state television, he declared the following: "Your holding this symbolic position has restrained your freedom and hindered our entrusting you with certain responsibilities that you are fully qualified to undertake.

[12] In April 2022, Hamzah relinquished his royal title of prince, stating his "personal convictions" were not in line with "the approaches, trends and modern methods of our institutions".

[14] In May 2022, the King formally announced that Hamzah had been put under house arrest and his communications and movements were limited due to his "erratic behavior and aspirations".

The couple issued a total of four daughters and two sons: Queen Noor (2003) Leap of Faith: Memoirs of an Unexpected Life, Miramax Books, ISBN 0-7868-6717-5