Due to their often excellent tolerance to powdery mildew, other fungal diseases, nematodes, and phylloxera, hybrid varieties have, to some extent, become a renewed focus for European breeding programs.
During the first half of the 20th century, various breeding programs were developed in an attempt to deal with the consequences of the Phylloxera louse, which was responsible for the destruction of European vineyards from 1863 onwards.
However, hybrid grape varieties were introduced as a solution to many of the viticulture problems of shorter-season, cooler and more humid wine regions, such as those in the northeast and Pacific Northwest of North America.
Hybrid grapes are expanding in traditional vinifera wine regions, because they can be easier to grow and can ripen earlier than vinifera (which reduces bird predation and reduces the risk of fruit hanging into the Fall rains), and because they typically have much more disease resistance (thereby requiring less spraying, which lessens tractor fuel usage and the volume of spray applications).
The best-known grape species in reference to viticulture include: While rare, interspecific hybrid vines can result in the wild from cross-pollination.