This oath is used by physicians in order to swear before various healing gods, one of which being Hygieia, that they would follow a code of established ethical standards of practice.

[7] In addition to statues which represent the two figures, the incorporation of Hygieia within the cult of Asclepius can also be seen in medical iconography on numerous ancient Graeco-Roman coins.

At the Asclepeion of Titane in Sicyon (founded by Alexanor, Asclepius' grandson), the Greek historian Pausanias remarked that a statue of Hygieia was covered by women's hair and pieces of Babylonian clothes.

One of the artificers, the quickest and the handiest workman among them all, with a slip of his foot fell down from a great height, and lay in a miserable condition, the physicians having no hope of his recovery.

When Pericles was in distress about this, the goddess [Athena] appeared to him at night in a dream, and ordered a course of treatment, which he applied, and in a short time and with great ease cured the man.

In the surviving depictions, she is often shown as a young woman feeding a large snake that was wrapped around her body or drinking from a jar that she carried.

In August 2021, archaeologists from Dumlupınar University announced the discovery of statue of Hygieia in the Ancient Greek city Aizanoi.