The limestone plain where it grows naturally in Ohio, the largest population within the bounds of the United States, is privately owned by a quarrying company that mines the rock.

[9] In some areas supporting the plant, lack of a natural fire regime allows ecological succession to occur in the nearly barren habitat, so that woody vegetation grows and blocks sunlight.

Because each plant requires pollen from an unrelated individual in order to reproduce, small, widely spaced populations make reproduction difficult.

[9] The USFWS 2016 final ruling as a part of its Five year Review of recovery efforts for the Lakeside Daisy identified threats to survival as habitat destruction, succession of competitive overgrowth by woody species, over-acting for gardens, inadequacy of existing regulatory mechanisms, and self-incompatibility.

[10] Since the Lakeside Daisy requires a strictly dry, limestone-based habitat, climate change is likely to have a significant impact on existing natural populations.

As quarry operations continue in these habitats, the areas best suited for Lakeside Daisy growth will likely fill with water and develop into small lakes.

[12] In an effort to help nearby land be more suitable for the plant to expand, wooded areas specifically near the Ohio populations may require management and clearing.

[10] Nonetheless, in recent years Lakeside Daisies have faced competition from native prairie plants, which often create a dense organic layer of soil.