This sequel contains both new and returning characters, and the gameplay has been updated so as to remove the random encounter feature.

A portable remaster titled Hyperdimension Neptunia Re;Birth2: Sisters Generation was made and released for the PlayStation Vita in 2014–2015 globally, later also for Windows.

While in a dungeon, various actions can be performed, mainly the Treasure Search and the Symbol Attack.

When the O button is pressed, the player scans the area to find hidden treasure.

Hitting it with a Symbol Attack gives the player's party the upper hand, and may sometimes even defeat the enemy.

Likewise, if the player character is approached from behind, the battle will start with a Back Attack and the enemy will gain the advantage.

Normal attacks and items consume AP until the points run out, after which the character's turn ends.

Each character is also assigned SP, or Skill Points, for performing skills or activating HDD (Hard Drive Divinity) in the case of the CPUs (Console Patron Units, the goddesses) or the CPU Candidates.

The character may perform normal attacks, use skills, activate HDD (only CPUs and CPU Candidates), or end their turn.

They may also switch between standby characters using AP and SP, escape from unscripted battles (dependent on Luck stat), or use items.

In this state, the defense stat and resistances of the target are significantly reduced until the enemy's GP completely recovers.

In some cases, to synthesize an item, a specific character's Lily Rank must be high enough to begin synthesis.

Over the years, the influence of ASIC has become increasingly powerful, currently affecting many residents of Gamindustri.

As such, in response to the threat, the CPUs and Nepgear travel to the Gamindustri Graveyard to combat ASIC.

Retreating to Planeptune, Nepgear must recover her strength and free Gamindustri from the influence of ASIC, though she must first locate the mascots of the landmasses, who can provide the power to potentially assist the captive CPUs.

As she travels Gamindustri to find the mascots, she crosses paths with Nisa, Gust, 5pb, Cave, and Falcom, as well as the other CPU Candidates, who she befriends.

They eventually join Nepgear's party, and together with the power of the mascots, they manage to free their captive sisters.

The members of ASIC fall by their hand as well, though they uncover a sinister plot to use their power to revive Arfoire.

Making their way to the Gamindustri Graveyard for the last time, Nepgear's party defeats Arfoire, and the CPUs attempt to seal the entity forever.

A direct reference to the PlayStation series, due to the majority of the landmass's buildings being colored black.

In addition to the original sisters, other characters that make return appearances include Compa, IF, 5pb, Some of the new characters include: The game was developed with assistance from Nippon Ichi Software, Gust Corporation, 5pb., and Comcept by Keiji Inafune.

It is the sequel to the previous game named Hyperdimension Neptunia, announced on April 12, 2011 for the PlayStation 3.

[6] Hyperdimension Neptunia mk2 was made available as a downloadable title on the PlayStation Network in August 2012.

Hyperdimension Neptunia Re;Birth2: Sisters Generation is an enhanced portable version of the game for the PlayStation Vita developed by Felistella, announced by Idea Factory and Compile Heart during a streamed interview at Tokyo Game Show 2013.

Roleplay Star Girl" (きりひらけ！ロープレ☆スターガール) by Nao, and the credits theme song is "Never give up" by Ayane.

Glazy☆Star (きりひらけ!グレイシー☆スター) performed by nao, the ending theme is GO→Love&Peace by Ayane, and an insert song is titled Crystal no Chikai (クリスタルの誓い) by YuiKaori.

[14] The PlayStation Vita rendition, Hyperdimension Neptunia Re;Birth2: Sisters Generation, was given a review score of 32/40 by Famitsu.