Hypericum bupleuroides is a species of perennial flowering plant in the St John's wort family, Hypericaceae.

Hypericum bupleuroides has a small distribution and specific habitat requirements that make it vulnerable to environmental pressures.

These include essential oils and secondary metabolites that are common to the genus Hypericum like hypericin, hyperforin, and various phenols.

It also has a greater concentration of some compounds than the type species of the genus, Hypericum perforatum, including chlorogenic acid and amentoflavone.

It is the sole member of the section Bupleuroides, to which it was assigned by Norman Robson in his monograph of the genus Hypericum.

[1] The most notable characteristic of the species' leaves are that they are perfoliate: the stem appears to puncture the center of the leaf.

The seed inside is a reddish brown color and is 0.12–0.15 cm long with a roughly cylindric shape that has a slight curve.

[1] Most species in the genus Hypericum have secondary metabolite extracts made up primarily of phytochemicals such as hypericin, hyperforin, and phenols.

[4] While a 2009 study did find these compounds, they were found in lower concentrations than in the genus type species Hypericum perforatum.

Further, it found comparable amounts of hyperoside, and greater concentrations of chlorogenic acid, apigenin 7-O-glucoside, and amentoflavone.

[10] Additionally, extracts from the species also have antibacterial capabilities, demonstrating a similar effect as the commercial antibiotic kanamycin A towards the bacteria hay bacillus and Candida albicans.

[1] The first reference to the modern name H. bupleuroides comes from a description of Hypericum rochelii by Johann Jakob Griesbach in 1852, in which the two species were compared to each other.

[1] In his monograph of the genus Hypericum, Norman Robson proposed that the nearest relative to H. bupleuroides was H. elatoides.

[15] One parasite that is hosted by H. bupleuroides is the moth Ectoedemia septembrella, the larvae of which bore into the leaves of the species.

[17] Hypericum bupleuroides has a limited distribution and requires a highly specific habitat to survive, which increase its risk for extinction.

[2] Methods like propagation by callus induction could be used to re-establish the species in its native habitat and combat environmental pressures.