Hypericum punctatum, the spotted St. John's wort, is a perennial herb native to North America.

[2] The yellow-flowered herb occurs throughout eastern North America into southern Canada.

The root system consists of a branching taproot and several short rhizomes from which vegetative colonies of the herb can grow.

[6] The leaves of the herb are 2–6 cm (0.79–2.36 in) long and are situated opposite on the glabrous stem, either sessile or with very short petioles.

The leaves vary in shape from oblong to elliptic or ovate, have rounded points at their apex, and taper towards their base.

The inflorescence is composed of a corymbiform cluster of terminal cymes crowded with many yellow flowers that measure 0.8–1.5 cm (0.31–0.59 in) in width.

These numerous stamens are situated in three principal bundles and vary in filament length.

The anthers are about 0.5 mm (0.020 in) in diameter and have divergent yellow thecae and purplish black connective.

Megasporogenesis is similar to microsporogenesis in the tendency to form chains and in the alternation of chromosomes in the first metaphase.

[13] Hypericum punctatum is common in floodplains, roadsides, moist fields, and thickets.

[11] It can be found throughout the American Midwest and the Atlantic coast and into Canada in Nova Scotia, Ontario, and Quebec.