[1] Causes include kidney failure, pseudohypoparathyroidism, hypoparathyroidism, diabetic ketoacidosis, tumor lysis syndrome, and rhabdomyolysis.

Abnormalities in phosphate metabolism such as hyperphosphatemia are included in the definition of the new chronic kidney disease–mineral and bone disorder (CKD–MBD).

[citation needed] Drugs: hyperphosphatemia can also be caused by taking oral sodium phosphate solutions prescribed for bowel preparation for colonoscopy in children.

[5] If the kidneys are operating normally, a saline diuresis can be induced to renally eliminate the excess phosphate.

In extreme cases, the blood can be filtered in a process called hemodialysis, removing the excess phosphate.