Hypoalgesic effects can be mild, such as massaging a stubbed toe to make it hurt less or taking aspirin to decrease a headache, or they can be severe, like being under strong anesthesia.
These can be released in response to a number of things, including increased blood pressure, pain and danger.
Many studies have shown the direct link between the two by subjecting patients to exercise and rating their pain responses, but despite the great deal of research, the mechanism of action is still poorly understood.
It has been shown that the triggering mechanism for the hypoalgesic effects is caused by the increase in blood pressure that accompanies a good workout.
It has been well documented that fear does cause a decrease in pain response,[6] however much like the exercise induced hypoalgesia, the exact mechanisms of action are not well understood.
Studies have shown that opioids are definitely involved in the process, yet opiates alone do not completely explain the analgesic response.
Some diseases, like CIPA, are hereditary disorders where genes essential for the correct functioning of nociceptors no longer work.
Just like in Exercise-Induced Hypoalgesia, the increased blood pressure of hypertension works as a signal to the body to release opioids and activate other pain modulation pathways.