In contrast with hyperhidrosis, which is a socially troubling yet often benign condition, the consequences of untreated hypohidrosis include hyperthermia, heat stroke and death.
[2] An extreme case of hypohidrosis in which there is a complete absence of sweating and the skin is dry is termed anhidrosis.
[citation needed] Magnetic resonance imaging of the brain and ⁄ or spinal cord is the best modality for evaluation when the lesion is suspected to be localized to the central nervous system.
Biopsy results may reveal the sweat gland destruction, necrosis or fibrosis, in addition to the findings of the primary dermatological disorder.
In these instances, prevention of further neurological damage, such as good glycaemic control in diabetes, is the cornerstone of management.