The hypothenar muscles are a group of three muscles of the palm that control the motion of the little finger.

The three muscles are:[1] The muscles of hypothenar eminence are from medial to lateral: The intrinsic muscles of hand can be remembered using the mnemonic, "A OF A OF A" for, Abductor pollicis brevis, Opponens pollicis, Flexor pollicis brevis (the three thenar muscles), Adductor pollicis, and the three hypothenar muscles, Opponens digiti minimi, Flexor digiti minimi brevis, Abductor digiti minimi.

[2] "Hypothenar atrophy" is associated with the lesion of the ulnar nerve, which supplies the three hypothenar muscles.

Hypothenar hammer syndrome is a vascular occlusion of this region.

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