[4] He had served the local dynasts (frataraka) of Persis, who had been able to reign independently for three decades from Greek Seleucid authority, and even briefly seize the region of Characene.

[2] After the city was fully restored in 166/5 BC, Antiochus IV appointed Hyspaosines as governor (eparch) of Antiochia and its surroundings.

[2] During this period Antiochia briefly flourished, until Antiochus IV's premature death by disease in 163 BC, which weakened Seleucid authority throughout the empire.

[2] With the weakening of the Seleucids, many political entities within the empire declared independence, such as the neighbouring region of Characene, Elymais, which was situated in most of the present-day province of Khuzestan in southern Iran.

[2] Hyspaosines' keenness to remain as a Seleucid governor was possibly due to avoid interruption in the profitable trade between Antiochia and Seleucia.

[2] In 127 BC, Mithridates I's son and successor Phraates II met an abrupt death during his war with the nomads in the east.