After these deeds, Alexander named him viceroy of the Indus area, around 325 BC, to the east of the territory held in the Paropamisadae by the satrap Oxyartes and to the south of the territories where Philip, son of Machatas was satrap: Later, Peithon managed putting down the revolt of king Musicanus (Indian: Mûshika) at the head of the Indus: Peithon was confirmed in his position at the Partition of Babylon following the death of Alexander in 323 BC: According to the text of the Partition of Triparadisus in 321 BC, Peithon was again confirmed in his dominion over the area beyond the Hindu-Kush: According to other sources, he was also at one point satrap of the Punjab.
In 317 BC, another Peithon, the satrap of Media, tried to control the eastern rulers of the Empire.
About that time, Chandragupta Maurya began conquering the northwestern territories held by the Greeks.
At the Battle of Gaza in autumn 312 BC, the Egyptian side under Ptolemy won, and Peithon was killed in action.
It is unknown what happened in India right after his departure, but ancient sources reported that the prefects of Greek territories were assassinated in the Indian uprisings led by Chandragupta Maurya: