Influenced by Nachman Krochmal, by Rapoport, and by Leopold Zunz's Gottesdienstliche Vorträge, Weiss devoted part of his time to the study of religious philosophy.
To the former he contributed articles on general subjects, as well as verses and a number of biographies, among which that of Rab (Abba Arika) deserves special notice.
In Vienna, where Jellinek and other prominent Jewish scholars were congregated, Weiss found greater scope for his literary activity.
He immediately turned his attention to a Vienna edition of the Talmud, and the notes with which he provided most of the tractates give evidence of his vast erudition.
In the following year Weiss edited the Sifra with the commentary of Abraham ben David of Posquières; to this work he added a historical and linguistic introduction in nine chapters, and he provided the text with critical and exegetical notes entitled Masoret ha-Talmud, giving the variants of different manuscripts as well as an index showing the parallel passages in both Talmudim.
In 1864 Weiss took a prominent part in the Kompert trial, publishing a pamphlet entitled Neẓaḥ Yisrael in support of the testimony of Horowitz and Mannheimer with regard to the belief in the Messiah.
In the same year he edited the Mekilta, to which he added an introduction dealing with the historical development of both Halakha and Aggada, and a critical commentary entitled Middot Soferim.
No less important are his biographical sketches, among which are those of Maimonides, Rashi, and Jacob Tam (Bet Talmud, i., ii., and iii., and reprinted in book form under the title Toledot Gedole Yisrael).
As its German title, Zur Geschichte der Jüdischen Tradition, shows, it is a history of the Halakha, or oral law, from Biblical times until the expulsion of the Jews from Spain at the end of the 15th century.
In the third volume much space is devoted to the Aggada and the aggadists, and the author does not endeavor to find apologies for those seemingly strange passages in this part of the Talmud which serve as pretexts for those who seek to detract from its value.
As was to be expected, this work, adopted by the majority of Haskalah Talmudic scholars as the standard history of the oral law, called forth replies from some dissenters.
Yehuda Lifshitz wrote a refutation "Dor Yesharim" that received approbations from major Chareidi figures such as Chaim Ozer Grodzinski.