[11] From 1937 till 1946, Chundrigar practiced and read law, taking several cases on civil matters where he advocated for his clients at the Bombay High Court.

[14] He was appointed as Commerce Minister under the presidential administrations of the Viceroys of India, Archibald Wavell (1946) and Louis Mountbatten (1946-47).

[8] Peter Lyon, a reader emeritus in international relations, described Chundrigar as a "close supporter" of Mohammad Ali Jinnah in the Pakistan Movement.

[15] After the partition of India by the act of the British Empire that established Pakistan, Chundrigar endorsed Liaquat Ali Khan's bid for the premiership[citation needed] and was retained as the commerce minister in the administration of Prime Minister Liaquat Ali Khan on 15 August 1947.

He was recalled to Pakistan by the Foreign Office, which viewed his inability to understand the Pashtun culture as a possible factor in fracturing Afghan-Pakistan relations.

Muhammad when he enforced martial law at the request of Prime Minister K. Nazimuddin to control violent religious riots that occurred in Lahore, Pakistan.

[22] At the National Assembly, he established his reputation as more of a constitutional lawyer than a politician, and gained a lot of prominence in public for his arguments in favour of parliamentarianism when he pleaded the case of "Maulvi Tamizuddin vs. Federation of Pakistan".

[23] At the first session of the National Assembly, Chundrigar presented his plan to reform the Electoral College which was met with great parliamentary opposition by even his Cabinet ministers from the Republican Party and the Awami League.

[2] In 1960, Chundrigar traveled to Hamburg where he addressed the International Law Conference and suffered a hemorrhage while visiting in London.