IGEPAL CA-630

IGEPAL CA-630 is sold by Sigma-Aldrich and is claimed to be a "chemically indistinguishable" substitute for Nonidet P-40 (a trademark of Shell Chemical Company) which is no longer manufactured.

However, a 2017 publication reported that IGEPAL 630 was ten-fold more potent than Nonidet P-40 in a tubulin polymerisation assay.

[1] All IGEPAL CA surfactants are derived from octylphenol.

Different amounts of ethylene oxide are combined with this part to get a balance of hydrophobic/hydrophilic substances (measured by HLB).

This balance has an important impact on wetting detergency, foam, solubility, emulsification.