[6] The human protein inner mitochondrial membrane peptidase subunit 2 has two isoforms due to alternative splicing.

Tourette's syndrome is a complex neuropsychiatric disorder characterized by multiple motor and phonic tics.

In the clinical characterization of a patient with Tourette's, Petek et al. discovered a breakpoint in chromosome region 7q31.

Additional characterization identified that IMMP2L, a novel gene coding for the apparent human homologue of the yeast mitochondrial inner membrane peptidase subunit 2, was found to be disrupted by both the breakpoint in the duplicated fragment and the insertion site in 7q31.

Tourette syndrome has a complex etiology, and the underlying environmental and genetic factors responsible for this disease are still largely unknown.