Like the telethons in the US, the ITV Telethons also offered regional cut-ins by ITV companies all over the country, featuring personalities and local celebrities from that region such as Richard Whiteley for Yorkshire Television or Ruth Madoc for HTV Wales.

One regional cut-in for the 1992 Telethon took place in the grounds outside Granada TV, Quay Street studio, and a non-stop 27-hour live stage presentation 'The Blackpool Roadshow' was gifted and coordinated by brother and sister Shirley Pearson and Johnnie Doolan.

[6][7] The 1990 protest was modestly attended, whereas the 1992 protest with more than 1000 disabled people outside the LWT studios on the South Bank was credited with ending the Telethon series, and indirectly leading to developments such as Comic Relief, though in reality this had begun earlier, following the Live Aid concerts for a similar cause in 1985.

This protest group Block Telethon formally became the Disabled People's Direct Action Network in 1993, which campaigned with other organisations against discrimination and for civil rights, leading up to the Disability Discrimination Act 1995.

In June 1993 ITV decided to scrap the 1994 Telethon saying "viewers have grown tired of being asked to donate money to Television charity Appeals" and the "telethon format is tired and people no longer respond well to things that are old".