Born in Costești, Botoșani County, his family were peasants of Armenian origin who had arrived in the Moldavia region over a century earlier.

His parents Melcon and Roza were poor, which meant that their son struggled materially as he passed through A. T. Laurian High School in Botoșani and the University of Bucharest's medical faculty.

[2] When Iacobovici arrived in Transylvania, there were almost no Romanian surgeons in the province, methods of surgery were obsolete and Romanian-language teaching materials were scarce.

[1] In 1929, when he had Alexandru Pop appointed lecturer and, implicitly, his successor as clinic head, nearly all the senior physicians quit and went to other cities.

[3] Among the types of operations in which he innovated were surgery for gastric ulcer, biliary bypass, tuberculosis, lumbar region, neurovegetative features and war wounds; as well as working on thyroid pathology, pulmonary exeresis and renal tumors.

[4] Following the accidental death in 1933 of Ernest Juvara, head of the surgery clinic at Spitalul Brâncovenesc, Iacobovici was named as his replacement.