The Book of Acts and the Epistles of the Apostle Paul record that in the early Church, Christians used to meet in the homes of the faithful.
The wedding ceremony ("crowning") is analogous to Ordination, and the house is blessed with a rite that is based upon the Consecration of a Church.
According to Bishop Kallistos Ware, "[I]n Orthodox spirituality, [there is] no separation between liturgy and private devotion.
Relics of saints (if the family possesses any) and a Gospel Book and a blessing cross would be kept there, as well as incense, holy water, palms and pussywillow from Palm Sunday, candles from Pascha (Easter), and other sacred items, as well as a personal Commemoration Book (containing the names of family and loved ones, both living and departed, to be remembered in prayer).
Ideally, the icon corner is located so that it is visible when one first enters the house from the main entrance.