While her spouse was the lover of Elisabet von Eyben, she had an affair with the Spanish envoy Sebastian de Llano y la Quadra.
Although her spouse was on the queen's side against the king's favorite Conrad Holck, he lost his office in 1771 and the couple had to leave court.
When Moltke died shortly after, a scandal occurred when his widow was accused of having caused his death by infecting him with a venereal disease, by having caused him to commit suicide out of sorrow because of her adultery, or by having been poisoned by her and her lover courtier nobleman Karl Adolf von Plessen.
In 1771, she married Karl Adolf von Plessen shortly after she became a widow, which made them suspicious.
Her preserved correspondence is generally regarded as a valuable historic source about the courtiers of the Danish royal court of her time.