SH-22 begins at SH-33 near Arco and travels northeast across the desert before intersecting SH-28 and slowly bending east, passing by some farmland.

The highway ends in the city of Dubois at a diamond interchange with I-15.

The route of the original SH-22 was based on Sampson Trails G and H from Mountain Home to Trude,[3] which are essentially the route of today's US 20 from Mountain Home through Arco to Idaho Falls and US 26 east from there.

The current configuration is based on the original SH-29 from the 1937 map.

[4] Media related to Idaho State Highway 22 at Wikimedia Commons